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QUESTION: Does oral antimicrobial prophylaxis reduce the number of urinary tract infections (UTIs) in people with neurogenic bladder resulting from spinal cord dysfunction (SCD)?
Studies of any language were identified by searching Medline (1966 to January 1998), EMBASE/Excerpta Medica (1974 to January 1998), and CINAHL (1982 to July 1998). Additional studies were identified by panel members and from bibliographies of relevant papers.
Studies were selected if they were randomised controlled trials of adolescents and adults with neurogenic bladder resulting from SCD who received treatment to prevent recurrent UTI and the outcomes included asymptomatic (bacteriuria) or symptomatic UTI.
Data were extracted on study population, specific treatments, group size, outcomes measured, and results. Main outcome was weekly infection rate, …