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Pacifiers have greater analgesic effect than sweet solutions during venipuncture in full term newborns

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 QUESTION: In full term newborns having venipuncture, what are the analgesic effects of glucose, sucrose, and pacifiers?


Randomised (allocation concealed*), blinded (outcome assessor was blinded to type of solution but not to the pacifier),* placebo controlled trial.


Maternity ward of a hospital in Poissy, France.


150 eligible newborns (59% boys) who had a 5 minute Apgar score ≥7, were medically stable, had not received naloxone during the previous 24 hours, and were not fed in the previous 30 minutes. 50 eligible newborns were not randomised because of non-availability of the observer …

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