Therapeutics
The implantable cardioverter defibrillator did not reduce mortality in ventricular arrhythmia
Connolly SJ, Gent M, Roberts RS, et al, for the CIDS Investigators. Canadian Implantable Defibrillator Study (CIDS). A randomized trial of the implantable cardioverter defibrillator against amiodarone. Circulation2000 Mar 21;101:1297–1302.
Oral amiodarone was effective and safe for recent-onset atrial fibrillation
Peuhkurinen K, Niemelä M, Ylitalo A, et al. Effectiveness of amidarone as a single oral dose for recent-onset atrial fibrillation. Am J Cardiol2000 Feb 15;85:462–5.
Review: Thienopyridines are more effective than aspirin for preventing vascular events in high-risk patients
Hankey GJ, Sudlow CL, Dunbabin DW. Thienopyridine derivatives (ticlopidine, clopidogrel) versus aspirin for preventing stroke and other serious vascular events in high vascular risk patients. Cochrane Review, latest version 24 Aug 1999. In: Cochrane Library Oxford: Update Software.
Review: Carotid endarterectomy for asymptomatic carotid stenosis does not reduce stroke or death
Chambers BR, You RX, Donnan GA. Carotid endarterectomy for asymptomatic carotid stenosis. Cochrane Review, latest version 19 Oct 1999. In: Cochrane Library Oxford: Update Software.
Low-dose rosiglitazone plus sulfonylurea was effective and safe for treating hyperglycemia in type 2 diabetes mellitus
Wolffenbuttel BHR, Gomis R, Squatrito S, et al. Addition of low-dose rosiglitazone to sulphonylurea therapy improves glycaemic control in Type 2 diabetic patients. Diabet Med2000 Jan;17:40–7.
Review: Quality of sedation in the ICU is similar for propofol and midazolam, but propofol shortens the time to extubation
Ostermann ME, Keenan SP, Seiferling RA, et al. Sedation in the intensive care unit. A systematic review. JAMA2000 Mar 15;283:1451–9.
Review: Riluzole increases 12-month survival in amyotrophic lateral sclerosis
Miller RG, Mitchell JD, Moore DH. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Review, latest version 26 Oct 1999. In: Cochrane Library Oxford: Update Software.
Ketoprofen given twice daily and interferon-α 2b increased and maintained response in chronic HCV-related liver disease
Muñoz AE, Levi D, Podestá A, et al. Interferon-α 2b combined with daily ketoprofen administration improves virological response in chronic hepatitis C: a prospective and randomised trial. Gut2000 Mar;46:427–31.
Review: Cisapride reduces overall and global symptoms in adults with non-ulcer dyspepsia, but study quality is poor
Shukla VK, Otten N, Dubé C, et al. Use of cisapride in patients with non-ulcer dyspepsia: a meta-analysis of randomized trials. Ottawa. Canadian Coordinating Office for Health Technology Assessment (CCOHTA); Feb 2000.
Diagnosis
SimpliRED d-dimer assay did not rule out venous thromboembolism in the emergency department
Farrell S, Hayes T, Shaw M. A negative SimpliRED d-dimer assay result does not exclude the diagnosis of deep vein thrombosis or pulmonary embolus in emergency department patients. Ann Emerg Med2000 Feb;35:121–5.
Review: high quality studies do not show reductions in breast cancer mortality for women screened with mammography
Gøtzsche PC, Olsen O. Is screening for breast cancer with mammography justifiable? Lancet2000 Jan 8;355:129–34.
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