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Therapeutics
Inhaled budesonide and prednisone led to similar rates of asthma relapse after emergency department discharge

http://dx.doi.org/10.1136/ebm.5.5.139

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    (2000) Can Respir J 7, 61. FitzGerald JM, Shragge D, Haddon J, et al.. A randomized, controlled trial of high dose, inhaled budesonide versus oral prednisone in patients discharged from the emergency department following an acute asthma exacerbation.. Jan/Feb;. :. –7.
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 QUESTION: In patients who are discharged from the emergency department after a severe acute asthma attack, do high doses of prednisone and inhaled budesonide lead to similar rates of asthma relapse?

    Design

    Randomised (unclear allocation concealment*), blinded {clinicians, patients, outcome assessors, and statisticians}†,* controlled trial with 7–10 day follow up.

    Setting

    3 university affiliated urban emergency departments in Canada.

    Patients

    185 patients who were 15–70 years of age, had an acute asthma exacerbation, were well enough to be discharged (postbronchodilator FEV1 > 50% of predicted normal rate), and were able to use Turbuhaler correctly. Exclusion criteria included chronic obstructive pulmonary disease, intolerance to systemic glucocorticosteroids, peptic ulcer disease, active tuberculosis, fungal infection, type 1 diabetes mellitus, moderate to severe hypertension, pregnancy, lactation, or no effective contraception use …

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    Footnotes

    • Source of funding: Astra Pharma Inc.

    • For correspondence: Dr J M FitzGerald, Respiratory Clinic, Vancouver Hospital and Health Sciences Centre, 2775 Heather Street, Vancouver, British Columbia V5Z 1J5, Canada. Fax +1 604 875 4695.

    • ↵* See glossary.

    • ↵† Information provided by author.