You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Review: glucosamine and chondroitin improve outcomes in osteoarthritis, but the magnitude of effect is unclear

https://doi.org/10.1136/ebm.5.5.146

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (2000) JAMA 283, 1469. McAlindon TE, LaValley MP, Gulin JP, et al.. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.. Mar 15;. :. –75.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 QUESTION: In patients with osteoarthritis (OA), are glucosamine and chondroitin effective for relieving symptoms and improving function?

    Data sources

    Studies were identified by searching Medline (1966 to June 1999) and the Cochrane Controlled Trials Register and reviewing bibliographies of reviews and manuscripts. Meeting abstracts published in supplements of Arthritis and Rheumatism, the British Journal of Rheumatology, and Osteoarthritis and Cartilage (1978–98) were handsearched. Authors, content experts, and drug manufacturers were contacted.

    Study selection

    Studies in any language were selected if they were randomised, double blind, controlled trials that compared oral or parenteral glucosamine sulfate, glucosamine hydrochloride, or chondroitin sulfate with placebo for ≥4 weeks in patients with OA of the knee or hip. Studies also had to include ≥1 outcome measure from a list compiled by the reviewers.

    Data extraction

    2 reviewers assessed the quality of studies (14 item …

    View Full Text

    Footnotes

    • Source of funding: National Institutes of Health.

    • For correspondence: Dr T E McAlindon, The Arthritis Center, Boston University School of Medicine, 715 Albany Street, A203, Boston, MA 02118, USA. Fax +1 617 638 5239.

    • A modified version of this abstract also appears in Evidence-Based Nursing.