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Therapeutics
Cisapride was effective in the short term for constipation in children

https://doi.org/10.1136/ebm.5.5.150

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    (2000) J Pediatr 136, 35. Nurko S, Garcia-Aranda JA, Worona LB, et al.. Cisapride for the treatment of constipation in children: a double-blind study.. Jan;. :. –40.
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 QUESTION: In children with constipation, what is the effectiveness of cisapride (a prokinetic agent)?

    Design

    12 week randomised (allocation concealed*), blinded {clinicians, patients, outcome assessors, and statisticians}†* placebo controlled trial.

    Setting

    Gastroenterology clinic of a hospital in Mexico City, Mexico.

    Patients

    40 children who were 2–16 years of age, had a history of chronic constipation, and had <3 bowel movements per week during a 2 week observation period before enrolment. Exclusion criteria were Hirschsprung disease, other congenital abnormalities of the gastrointestinal tract, or pelvic floor dyssynergia. Data were available for 36 patients (90%) (mean age 6 y, 67% boys).

    Intervention

    Patients were disimpacted and allocated to cisapride (n=17) or placebo (n=19) for 12 weeks. The medications were given as an oral suspension, 0.2 mg/kg of body weight per …

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    Footnotes

    • Source of funding: In part, Janssen Pharmaceutics.

    • For correspondence: Dr S Nurko, Pediatric Gastroenterology, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.

    • ↵* See glossary.

    • ↵† Information provided by author.