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  • Patients with carotid artery stenosis had a high risk for stroke, and some types of stroke were not prevented by endarterectomy

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Aetiology
Patients with carotid artery stenosis had a high risk for stroke, and some types of stroke were not prevented by endarterectomy

https://doi.org/10.1136/ebm.5.5.155

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    (2000) JAMA 283, 1429. Barnett HJ, Gunton RW, Eliasziw M, et al.. Causes and severity of ischemic stroke in patients with internal carotid artery stenosis.. Mar 15;. :. –36.
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 QUESTION: In patients with internal carotid artery (ICA) stenosis, what are the causes and severity of stroke for varying degrees of stenosis?

    Design

    Cohort study using data from the North American Symptomatic Carotid Endarterectomy Trial (NASCET) with mean follow up of 5 years.

    Setting

    106 centres mostly in North America.

    Patients

    2885 patients (median age 67 y, 70% men) with ICA stenosis.

    Assessment of risk factors

    ICA stenosis measured by angiography and duplex ultrasonography; categories of stenosis were <60%, 60% to 69%, and 70% to 99%.

    Main outcome measures

    Ischaemic strokes were classified as large artery, lacunar, or cardioembolic (possible or probable) strokes. Severity was also assessed (non-disabling, disabling, or fatal).

    Main results

    During follow up, 749 patients had 1039 …

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    Footnotes

    • Source of funding: National Institute of Neurological Disorders and Stroke.

    • For correspondence: Dr H J Barnett, John P Robarts Research Institute, PO Box 5015, 100 Perth Drive, London, Ontario N6A 5K8, Canada. Fax +1 519 663 3789.