You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Tiotropium improved lung function more than ipratropium in chronic obstructive pulmonary disease

https://doi.org/10.1136/ebm.5.6.169

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (2000) Thorax 55, 289. van Noord JA, Bantje Th A, Eland ME. , et al, on behalf of the Dutch Tiotropium Study Group.. A randomised controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease.. Apr;. :. –94.
    OpenUrlAbstract/FREE Full Text

    
 
 QUESTION: In patients with stable chronic obstructive pulmonary disease (COPD), what is the long term effectiveness and safety of tiotropium compared with those of ipratropium?

    Design

    Randomised {allocation concealed*}†, blinded (patient and outcome assessor),* controlled trial with 13 weeks of follow up.

    Setting

    14 centres in the Netherlands.

    Patients

    288 patients ≥40 years of age (mean age 64 y, 83% men) who were current or past smokers with a diagnosis of COPD and stable airways obstruction, an FEV1 < 65% of the predicted normal rate, and a ratio of FEV1 to forced vital capacity (FVC) of <70%. Exclusion criteria included a history of asthma, allergic rhinitis, or atopy; a recent history of myocardial infarction, heart failure, or cardiac arrhythmia requiring drug treatment; upper respiratory tract …

    View Full Text

    Footnotes

    • Source of funding: Boehringer Ingelheim BV.

    • For correspondence: Dr J A van Noord, Department of Respiratory Diseases, Atrium Medisch Centrum, Henri Dunantstraat 5, 6419 PC Heerlen, the Netherlands. Fax +31 455767534.

    • ↵* See glossary.

    • ↵† Information provided by the author.