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Angioplasty was no better than medication for reducing blood pressure or slowing disease progression in renal artery stenosis

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 QUESTION: In patients with atherosclerotic renal artery stenosis who have normal or mildly impaired renal function, is balloon angioplasty as effective as antihypertensive drug treatment for reducing blood pressure?


Randomised (allocation concealed*), blinded {outcome assessors},* controlled trial with 12 months follow up.


26 clinical centres in the Netherlands.


106 patients (mean age 60 y, 62% men) with renal artery stenosis measured by renal arteriography (reduction in luminal diameter ≥50%) and normal to mildly impaired renal function (serum creatinine level ≤2.3 mg/dl [200 μmol/l]). Exclusion criteria were cancer, hypertension caused by a condition other than renovascular disease, unstable coronary artery disease, heart failure, or pregnancy. Follow up was 98%.


56 patients were allocated to …

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  • Source of funding: Dutch Health Insurance Executive Board.

  • For correspondence: Dr B C van Jaarsveld, Dianet Dialysis Centres, Brennerbaan 130, 3524 BN Utrecht, the Netherlands. Fax +31 30 281 7094.

  • * See glossary.

  • Information provided by author.