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Review: aspirin lowers the risk for MI but not for stroke in people who do not have established vascular disease

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 QUESTION: For people who do not have clinically recognised vascular disease, is aspirin effective for reducing stroke and other vascular events?

Data sources

Studies were identified by searching for English language articles in {Medline}* (1980–98) with the terms clinical trial, aspirin, and stroke; the Cochrane Collaboration Trials Registry; the Antiplatelet Trialists' Collaboration lists of publications; and bibliographies of review articles.

Study selection

Studies were selected if they were randomised controlled trials or large observational studies of aspirin in any dose; trials compared aspirin with placebo for primary prevention of stroke; data were provided on people who did not have established vascular disease at baseline; and outcomes were stroke, myocardial infarction, or other major vascular …

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  • Source of funding: no external funding.

  • For correspondence: Dr R G Hart, Department of Medicine (Neurology), University of Texas Health Science Center MSC7883, 7703 Floyd Curl Drive, San Antonio, TX 78229–3900, USA. Fax +1 210 567 4659.

  • * Information provided by author.