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Therapeutics
Hormone replacement therapy was associated with increased venous thromboembolism and deep venous thrombosis

https://doi.org/10.1136/ebm.5.6.175

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    (2000) Ann Intern Med 132, 689. Grady D, Wenger NK, Herrington D. , et al, for the Heart and Estrogen/progestin Replacement Study Research Group.. Postmenopausal hormone therapy increases risk for venous thromboembolic disease. The heart and estrogen/progestin replacement study.. May 2;. :. –96.
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 QUESTION: In women with coronary artery disease, does hormone replacement therapy (HRT) (oestrogen plus progestin) increase the risk for venous thromboembolism (VTE)?

    Design

    Randomised (unclear allocation concealment*), blinded (patients, investigators, and outcome assessors),* placebo controlled trial with a mean follow up of 4.1 years (Heart and Estrogen/progestin Replacement Study [HERS]).

    Setting

    20 US outpatient and community settings.

    Patients

    2763 postmenopausal women between 44 and 79 years of age (mean age 67 y, 89% white) who had established coronary artery disease and who had not had a hysterectomy. Exclusion criteria were recent coronary events; recent use of hormone therapy; history of VTE, breast cancer, or endometrial cancer; uncontrolled hypertension; diabetes; or other life …

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    Footnotes

    • Source of funding: Wyeth-Ayerst Laboratories.

    • For correspondence: Dr D Grady, University of California, San Francisco, 74 New Montgomery Street, Suite 600, San Francisco, CA 94105, USA. Fax +1 415 386 4044.

    • A modified version of this abstract also appears in Evidence-Based Nursing.

    • ↵* See glossary.