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  • Adding 3 dose artesunate to pyrimethamine sulfadoxine reduced treatment failure in children with acute uncomplicated malaria

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Therapeutics
Adding 3 dose artesunate to pyrimethamine sulfadoxine reduced treatment failure in children with acute uncomplicated malaria

https://doi.org/10.1136/ebm.5.6.176

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    (2000) Lancet 355, 352; von Seidlein L, Milligan P, Pinder M. , et al.. Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial.. Jan 29;. :. –7.
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 QUESTION: In Gambian children with acute uncomplicated malaria, is pyrimethamine sulfadoxine (PS) and artesunate more effective than PS alone for Plasmodium falciparum malaria?

    Design

    Randomised (allocation concealed*), blinded (patients, parents, and investigators),* placebo controlled trial with 28 day follow up.

    Setting

    5 health centres in the Gambia (1 in a semiurban coastal area and 4 in the rural inland region).

    Patients

    600 children who were <10 years of age (mean age 5 y, 52% boys), weighed >5 kg, were infected with P. falciparum at a density of ≥500/μl, had a history of fever, and lived within 20 km of a trial centre. Exclusion criteria were requirement for parenteral treatment, treatment within the previous 2 weeks with PS, a haematocrit concentration …

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    Footnotes

    • Source of funding: UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR).

    • For correspondence: Dr L von Seidlein, International Vaccine Institute, Seoul National University Campus, Shillim-Dong, Kwahak-gu, Seoul 151742, Korea.

    • ↵* See glossary.

    • ↵† p Value calculated from data in article.