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Therapeutics
Risk for mother to child HIV-1 infection was increased by breast feeding

https://doi.org/10.1136/ebm.5.6.177

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    (2000) JAMA 283, 1167. Nduati R, John G, Mbori-Ngacha D. , et al.. Effect of breastfeeding and formula feeding on transmission of HIV-1. A randomized clinical trial.. Mar 1;. :. –74.
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 QUESTION: In the infants of HIV-1 infected women, does formula feeding instead of breast feeding reduce the rate of HIV-1 transmission and mortality?

    Design

    Randomised (allocation concealed*), blinded (investigators to interim results),* controlled trial with 2 year follow up.

    Setting

    4 antenatal clinics in Nairobi.

    Patients

    425 HIV-1 infected pregnant women (mean age 23 y) who resided in Nairobi and had access to municipally treated water. 401 mother-infant pairs (94%) were included in the analysis.

    Intervention

    Women were allocated to breast feed (n=212) or formula feed (n=213) their infants. Women in the formula feed group were told to feed their infant with a cup and had to demonstrate proper formula preparation and cup feeding to a visiting nurse.

    Main outcome measures

    Infant HIV-1 infection and mortality …

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