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Therapeutics
Verapamil reduced attack frequency and the use of abortive agents in episodic cluster headache

https://doi.org/10.1136/ebm.5.6.178

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    (2000) Neurology 54, 1382. Leone M, D'Amico D, Frediani F. , et al. . Verapamil in the prophylaxis of episodic cluster headache: a double-blind study versus placebo. . . Mar;. :. –5..
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 QUESTION: What is the effectiveness of verapamil as a prophylaxis for episodic cluster headache?

    Design

    Randomised {allocation concealed*},† blinded {clinicians, patients, and outcome assessors*},† placebo controlled trial with 2 week follow up.

    Setting

    3 outpatient clinics in Italy.

    Patients

    30 adults between 18 and 60 years of age (mean age 44 y, 90% men) who were outpatients and had a diagnosis of episodic cluster headache (International Headache Society criteria) with ≥1 previous cluster period lasting ≥1 month and who had been in a cluster period for ⩽10 days and had an expected duration of the remainder of the cluster period of ≥20 days. Exclusion criteria were …

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    Footnotes

    • Source of funding: no external funding.

    • For correspondence: Dr G Bussone, Istituto Nazionale Neurologico Carlo Besta, via Celoria 11, 20133 Milan, Italy. Fax +39 02 7063 8067.

    • ↵* See glossary.

    • ↵† Information provided by author.

    • ↵‡ p Value calculated from data in article.