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Verapamil reduced attack frequency and the use of abortive agents in episodic cluster headache

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 QUESTION: What is the effectiveness of verapamil as a prophylaxis for episodic cluster headache?


Randomised {allocation concealed*}, blinded {clinicians, patients, and outcome assessors*}, placebo controlled trial with 2 week follow up.


3 outpatient clinics in Italy.


30 adults between 18 and 60 years of age (mean age 44 y, 90% men) who were outpatients and had a diagnosis of episodic cluster headache (International Headache Society criteria) with ≥1 previous cluster period lasting ≥1 month and who had been in a cluster period for ⩽10 days and had an expected duration of the remainder of the cluster period of ≥20 days. Exclusion criteria were …

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  • Source of funding: no external funding.

  • For correspondence: Dr G Bussone, Istituto Nazionale Neurologico Carlo Besta, via Celoria 11, 20133 Milan, Italy. Fax +39 02 7063 8067.

  • * See glossary.

  • Information provided by author.

  • p Value calculated from data in article.