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The recurrence rate of venous thromboembolism after a first or second episode of deep venous thrombosis was high

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 QUESTIONS: For patients who had a first or second episode of confirmed arm or leg deep venous thrombosis (DVT), what is the incidence of recurrent venous thromboembolism (VTE) (DVT or pulmonary embolism [PE]), and what are the risk factors for recurrence?


Cohort study with 3.7 to 8.8 years of follow up.


A university hospital in Göteborg, Sweden.


738 patients with DVT confirmed by phlebography or color duplex ultrasonography who had been discharged from the hospital and survived to 1 month. 591 patients (mean age 66 y, 53% women) had a first DVT, and 147 patients had previous VTEs (108 patients with a previous DVT, 19 with a previous PE, and 20 with both DVT and PE). Follow up for mortality was >99%.

Assessment of prognostic factors

Data on prognostic factors were collected and used in multivariate analyses: …

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  • Sources of funding: Swedish Medical Research Council; King Gustav V and Queen Victoria Foundation; Göteborg Medical Association; Göteborg University.

  • For correspondence: Dr P O Hansson, Department of Medicine, Sahlgrenska University Hospital-Östra, SE-41685 Göteborg, Sweden. Fax +46 31 3388694.