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Aetiology
Review: silicone breast implants do not increase the risk for connective tissue diseases

https://doi.org/10.1136/ebm.5.6.189

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    (2000) N Engl J Med 342, 781. Janowsky EC, Kupper LL, Hulka BS.. Meta-analyses of the relation between silicone breast implants and the risk of connective-tissue diseases.. Mar 16;. :. –90.
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 QUESTION: Are silicone breast implants associated with an increased risk for connective tissue diseases (rheumatoid arthritis, systemic lupus erythematosus, scleroderma or systemic sclerosis, the Sjögren syndrome, dermatomyositis or polymyositis, all definite connective tissue diseases, or other autoimmune or rheumatic conditions)?

    Data sources

    Studies were identified by searching Medline, TOXLINE, Current Contents Online, and Dissertations Abstracts Online with terms related to breast implants and connective tissue diseases.

    Study selection

    Studies were selected if internal comparison groups were evaluated and sufficient data were available for analysis of women (not disease events) using 2 × 2 tables for categories of disease and implants.

    Data extraction

    Data were extracted on year and country of publication; funding; study design; population characteristics and numbers; type, date, and reason for implant; disease characteristics; time from implantation to symptoms; and confounding …

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    Footnotes

    • Source of funding: Administrative Office of the US Courts.

    • For correspondence: Dr E C Janowsky, Department of Epidemiology, CB 7400, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. esther_janowsky{at}unc.edu.com