Article Text

Download PDFPDF
On demand use of β2 agonists led to better asthma control than regular use in moderate to severe asthma

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 QUESTION: In patients with moderate to severe asthma, is on demand use of β2 agonists as effective and safe as regular use?


Randomised {allocation concealed*}, blinded (outcome assessors and statistician),* crossover trial with 24 weeks follow up for each treatment condition.


Outpatient clinic at Düsseldorf University Medical Centre in Germany.


80 patients (mean age 48 y, 74% women) with moderate to severe asthma on regularly scheduled β2 agonist (minimum daily intake of 6 puffs) and inhaled corticosteroids (ICS) for ≥2 years. Exclusion criteria were non-respiratory illnesses or pregnancy. 73 patients (91%) completed the study.


Two 24 week periods in which patients were allocated to on demand inhalation (salbutamol or fenoterol) or regular use of β2 agonist (2 inhalations 4 times daily plus salbutamol or fenoterol on demand) and crossed over to the …

View Full Text


  • Source of funding: no external funding.

  • For correspondence: Dr B Richter, Heinrich-Heine-Universität Düsseldorf, Klinik für Stoffwech-selkrankheiten und Ernährung, Moorenstrasse 5, Postfach 101007, D-40001 Düsseldorf, Germany. richterb{at}

  • A modified version of this abstract also appears in Evidence-Based Nursing.

  • * See glossary.

  • Information provided by author.