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Review: 3 to 7 months of prednisone is more effective than 2 months in children with steroid responsive nephrotic syndrome

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 QUESTION: In children with steroid responsive nephrotic syndrome (SRNS), what is the optimal corticosteroid regimen?

Data sources

Studies were identified by searching Medline (1966 to July 1998), EMBASE/Excerpta Medica (1988 to July 1998), and the Cochrane Controlled Trials Register (1998); scanning reference lists of relevant articles, nephrology textbooks, and proceedings of scientific meetings; and contacting investigators.

Study selection

2 reviewers independently selected studies if they were randomised or quasirandomised controlled trials, involved children who were 3 months to 18 years of age and had initial or subsequent episodes of SRNS, compared different regimens of prednisone or other corticosteroid agents, and reported ⩾6 months of follow up data.

Data extraction

2 reviewers independently extracted data on setting, publication year, number of patients in each group, dose and duration of treatments, study methods, …

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