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Review: the accuracy of troponin T and I tests in acute myocardial infarction depends on timing after onset of symptoms

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 QUESTION: Are troponin T and troponin I tests accurate for detecting acute myocardial infarction (MI) at varying times from onset of symptoms or presentation to the emergency department (ED)?

Data sources

Studies were identified by searching Medline to December 1999 with terms and phrases related to troponin, diagnosis, and diagnostic use.

Study selection

English, German, French, and Spanish language studies were selected if troponin tests were used in the assessment of adults with acute chest pain, the study design included prospective data collection, assessment of acute MI was made by clinicians blinded to the results of the troponin tests, MI was diagnosed using the World Health Organisation or similar criteria, and sensitivity and specificity data were reported for ≥1 time point from the onset of pain or presentation to the ED.

Data extraction

Data were extracted on settings, …

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