Article Text

Download PDFPDF

Review: evidence does not support an association between allergen levels and risk for asthma
Free

Statistics from Altmetric.com


 
 QUESTION: Is allergen exposure the major primary cause of asthma?

Data source

Medline search (from 1980).

Study selection

English language studies were selected if they were longitudinal or cross sectional studies of the relation between allergens and asthma. The review focused on primary causation studies that reported the amount of allergen exposure. Studies that used bronchial hyperresponsiveness in the definition of asthma were excluded. Studies of selected populations were used when no information from population based studies was available.

Data extraction

Data were extracted on age, allergen levels, asthma prevalence, definition of asthma, and population attributable risk.

Main results

Results are reported for longitudinal studies only. No population based studies were found on the relation between allergen exposure during infancy and asthma risk after the age of 6 years. In 1 randomised controlled trial, 160 infants with a family history of atopy were allocated to prophylaxis (avoidance of house dust mite allergen and allergenic food) or no …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.