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Amiodarone maintained sinus rhythm better than sotalol or placebo in atrial fibrillation, but adverse effects were more frequent

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 QUESTION: In patients with recurrent atrial fibrillation (AF), are amiodarone and sotalol safe and effective for maintaining sinus rhythm?


Randomised (allocation not concealed*), blinded (patients),* placebo controlled trial with mean follow up of 22 months.


A tertiary cardiac referral centre in a university hospital in Greece.


186 patients (mean age 63 y, 52% men) who had symptomatic chronic or paroxysmal AF confirmed by electrocardiography. Inclusion criteria were >18 years of age and successful chemical or electrical cadioversion to sinus rhythm. Exclusion criteria were recent acute myocardial infarction, cardiogenic shock, transient AF related to an ongoing disease or condition, unstable hepatic or renal function, ejection fraction <40%, hyperthyroidism, life expectancy <1 year, or previous exposure to study drugs. Follow up …

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  • Source of funding: no external funding.

  • For correspondence:Professor P E Vardas, Cardiology Department, University Hospital of Heraklion, PO Box 1352, Heraklion, Crete, Greece. Fax +30 81 542111.

  • * See glossary.