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Review: prokinetics and histamine-2 receptor antagonists improve symptom scores in non-ulcer dyspepsia

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 QUESTION: In patients with non-ulcer dyspepsia, what is the relative effectiveness of 6 classes of drugs in improving symptom scores and quality of life?

Data sources

Studies were identified by searching the Cochrane Controlled Trials Register, Medline (1966 to 1999), EMBASE/Excerpta Medica (1988 to 1999), CINAHL (1982 to 1999), and SIGLE. Members of the Cochrane Upper Gastrointestinal and Pancreatic Diseases Group, experts in the field of dyspepsia, and pharmaceutical companies with an interest in gastroenterology were contacted for details of unpublished trials.

Study selection

Studies were selected if they were randomised controlled trials that included adult patients with dyspepsia symptoms and compared 1 of 6 drug classes (antacids, histamine-2 receptor antagonists [H2RAs], proton-pump inhibitors, prokinetics, mucosal protection …

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  • Sources of funding: NHS Health Technology Assessment Programme; Medical Research Council; NHS Research and Development Programme.

  • For correspondence: Dr S Soo, 30-32 Hyde Terrace, Leeds LS2 9LN, UK. Fax +44 (0)113 233 6778.