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QUESTION: In patients with non-ulcer dyspepsia, what is the relative effectiveness of 6 classes of drugs in improving symptom scores and quality of life?
Studies were identified by searching the Cochrane Controlled Trials Register, Medline (1966 to 1999), EMBASE/Excerpta Medica (1988 to 1999), CINAHL (1982 to 1999), and SIGLE. Members of the Cochrane Upper Gastrointestinal and Pancreatic Diseases Group, experts in the field of dyspepsia, and pharmaceutical companies with an interest in gastroenterology were contacted for details of unpublished trials.
Studies were selected if they were randomised controlled trials that included adult patients with dyspepsia symptoms and compared 1 of 6 drug classes (antacids, histamine-2 receptor antagonists [H2RAs], proton-pump inhibitors, prokinetics, mucosal protection …