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Helicobacter pylori testing plus eradication was as effective and safe as prompt endoscopy for dyspepsia

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 QUESTION: Is Helicobacter pylori testing plus eradication as effective and safe as prompt endoscopy in patients with dyspepsia?


Randomised (allocation concealed*), unblinded,* controlled trial with 1 year follow up.


Primary care clinics in Odense, Denmark.


500 patients ≥18 years of age (median age 45 y, 54% women) who had had ≥2 weeks of dyspeptic symptoms (pain or discomfort in the epigastrium with or without heartburn, regurgitation, nausea, vomiting, or bloating) with a severity that required treatment or investigation. Exclusion criteria included treatment with ulcer healing drugs in the previous month, bleeding or anaemia, unintentional weight loss >3 kg, or previous gastric surgery. Follow up was 89%.


At entry, all patients were asked to discontinue any nonsteroidal anti-inflammatory drug (NSAID) use. 250 patients were allocated to H pylori testing plus eradication. In this group, H pylori infected patients received 2 weeks of lansoprazole, 30 mg twice daily; …

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  • Sources of funding: Odense University; Clinical Institute; Christenson-Ceson Foundation; A J Andersen and wife Foundation; Lundbeck's Foundation; Wyeth Lederle.

  • For correspondence: Dr A T Lassen, Department of Medical Gastroenterology S, Odense University Hospital, 5000 Odense C, Denmark. Fax+ 45 6611 1328.

  • * See glossary.