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Therapeutics
Zinc supplements increased growth more in stunted infants than in non-stunted infants

https://doi.org/10.1136/ebm.6.2.50

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    (2000) Lancet 355, 2021. Umeta M, West CE, Haidar J, et al.. Zinc supplementation and stunted infants in Ethiopia: a randomised controlled trial.. Jun 10;. :. –6.
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 QUESTION: In stunted and non-stunted infants, do zinc supplements promote growth?

    Design

    Randomised (unclear allocation concealment*), blinded (investigators and field assistants),* placebo controlled trial with 6 months of follow up.

    Setting

    Dodota Sire district, central Ethiopia, Africa.

    Patients

    100 stunted (length for age Z score [LAZ] <–2) and 100 non-stunted (LAZ >–2) infants who were 6 to 12 months of age. Inclusion criteria were apparent health and willing participation of mothers. Exclusion criterion was diagnosis of intestinal parasites. 90% (mean age 10 mo, 53% boys) of stunted and 94% (mean age 9 mo, 53% girls) of non-stunted infants completed the 6 months follow up.

    Intervention

    Stunted and non-stunted infants were matched by sex, age, and recumbent length and allocated within the pair to zinc supplement, 10 mg of zinc sulfate in 3 ml of …

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    Footnotes

    • Source of funding: Nestlé Foundation for the Study of the Problems of Nutrition in the World.

    • For correspondence: Professor C E West, Division of Human Nutrition and Epidemiology, Wageningen University, PO Box 8129, 6700 EV Wageningen, the Netherlands. Fax +31 317 4 83342.

    • ↵* See glossary.