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Post-herpetic neuralgia was not frequent or severe after a first episode of herpes zoster

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 QUESTION: In patients with a first episode of herpes zoster, what is the clinical course of the disease and the duration of pain?

Design

Inception cohort followed up for 12 months.

Setting

Catchment area of 100 000 people for 62 general practitioners in Iceland.

Patients

421 patients {mean age 42 y, 56% women}* who had a first episode of herpes zoster. Patients with a history of zoster were excluded. Follow up was complete at 1 year.

Assessment of prognostic factors

Sex and age.

Main outcome measures

Severity and duration of pain and prevalence of post-herpetic neuralgia.

Main results

Sex was not a predictor of post-herpetic neuralgia at any point during follow up. Age was a predictor of pain severity and duration. The odds ratio for pain per 10 years of age difference was 1.87 (95% CI 1.56 to 2.23) after 1 month, 2.11 (CI 1.56 to 2.84) after 3 months, and 2.33 (CI 1.48 to 3.69) after …

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Footnotes

  • Sources of funding: In part, Icelandic College of Family Physicians and Research Fund of the University of Iceland.

  • For correspondence:Dr S Helgason, Arbaer Health Care Centre, IS-110 Reykjavik, Iceland. on sh{at}centrum.is.

  • * Information provided by author.