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Therapeutics
Review: selective serotonin reuptake inhibitors reduce symptoms in premenstrual syndrome

https://doi.org/10.1136/ebm.6.3.75

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    (2000) Lancet 356, 1131. Dimmock PW, Wyatt KM, Jones PW, et al.. Efficacy of selective serotonin-reuptake inhibitors in premenstrual syndrome: a systematic review.. Sep 30;. :. –6.
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 QUESTION: In women with severe premenstrual syndrome (PMS), are selective serotonin reuptake inhibitors (SSRIs) effective?

    Data sources

    Studies were identified by searching Medline (1966–99), EMBASE/Excerpta Medica (1988–98), PsycLIT (1974–97), CINAHL (1982–99), and the Cochrane Controlled Trials Register database; scanning the reference lists of identified articles; and contacting the manufacturers of SSRIs.

    Study selection

    Studies were selected if they were randomised, double blind, placebo controlled trials investigating SSRIs in the management of PMS.

    Data extraction

    Data were independently extracted in duplicate on study design, patient characteristics, drug type and dose, outcome measures (primary outcome measure was reduction in overall PMS symptoms), and side effects.

    Main results

    15 studies met the selection criteria and involved 904 women (570 allocated …

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    Footnotes

    • Source of funding: no external funding.

    • For correspondence: Dr P W Dimmock, Academic Department of Obstetrics and Gynaecology, Keele University and North Staffordshire Hospital, Stoke on Trent ST4 6QG, UK. Fax +44 (0)1782 747319. Abstract and commentary also appear in Evidence-Based Mental Health.