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Therapeutics
Review: antidepressants improve symptoms of fibromyalgia

https://doi.org/10.1136/ebm.6.3.77

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    (2000) J Gen Intern Med 15, 659. O'Malley PG, Balden E, Tomkins G, et al.. Treatment of fibromyalgia with antidepressants. A meta-analysis.. Sep;. :. –66.
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 QUESTION: Are antidepressants efficacious in the treatment of fibromyalgia?

    Data sources

    Studies in any language were identified by searching Medline (1966 to June 1999), PsycLIT (1974–98), and EMBASE/Excerpta Medica (1974–98) with the terms fibromyalgia, fibrositis, and fibromyositis combined with various terms for antidepressive agents (including specific drug names); the Cochrane Library Clinical Trials Registry and Database of Systematic Reviews; Federal Research in Progress to identify unpublished trials; and bibliographies of reviewed articles.

    Study selection

    Studies were selected if they were randomised, placebo controlled trials with at least 1 group receiving an antidepressant and if they reported measurable outcomes.

    Data extraction

    Data were extracted on setting; country; dose, duration, and follow up of treatment; number of participants and demographics; assessment of comorbid disease; follow up losses; adverse effects; and outcomes. Methodological quality of individual trials was assessed using the Jadad scale.

    Main results

    13 trials (mean …

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    Footnotes

    • Source of funding: MacArthur Foundation Initiative on Depression in Primary Care.

    • For correspondence: Dr P G O'Malley, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, Washington, DC 20307-5001, USA. Fax +1 202 782 5036.