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QUESTION: Are antidepressants efficacious in the treatment of fibromyalgia?
Studies in any language were identified by searching Medline (1966 to June 1999), PsycLIT (1974–98), and EMBASE/Excerpta Medica (1974–98) with the terms fibromyalgia, fibrositis, and fibromyositis combined with various terms for antidepressive agents (including specific drug names); the Cochrane Library Clinical Trials Registry and Database of Systematic Reviews; Federal Research in Progress to identify unpublished trials; and bibliographies of reviewed articles.
Studies were selected if they were randomised, placebo controlled trials with at least 1 group receiving an antidepressant and if they reported measurable outcomes.
Data were extracted on setting; country; dose, duration, and follow up of treatment; number of participants and demographics; assessment of comorbid disease; follow up losses; adverse effects; and outcomes. Methodological quality of individual trials was assessed using the Jadad scale.
13 trials (mean …
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