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Glyburide was as safe and effective as insulin in gestational diabetes
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 QUESTION: Is glyburide as effective and safe as insulin in women with gestational diabetes mellitus?

Design

Randomised (allocation concealed*), unblinded,* controlled trial.

Setting

Maternal health clinics in San Antonio, Texas, USA.

Patients

404 women (mean age 29.5 y) who were between 11 and 33 weeks of gestation with a singleton pregnancy and who had gestational diabetes and fasting blood glucose concentrations ≥5.3 mmol/l and <7.8 mmol/l. Follow up was 100%.

Intervention

404 women were allocated to receive glyburide (n=201) or insulin (n=203). Glyburide was started at an oral dose of 2.5 mg and increased to 20 mg as needed. Insulin was started at a dose of 0.7 U/kg of actual body weight, given subcutaneously 3 times/day, and increased as needed. …

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