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Therapeutics
Glyburide was as safe and effective as insulin in gestational diabetes

https://doi.org/10.1136/ebm.6.3.79

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    (2000) N Engl J Med 343, 1134. Langer O, Conway DL, Berkus MD, et al.. A comparison of glyburide and insulin in women with gestational diabetes mellitus.. Oct 19;. :. –8..
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 QUESTION: Is glyburide as effective and safe as insulin in women with gestational diabetes mellitus?

    Design

    Randomised (allocation concealed*), unblinded,* controlled trial.

    Setting

    Maternal health clinics in San Antonio, Texas, USA.

    Patients

    404 women (mean age 29.5 y) who were between 11 and 33 weeks of gestation with a singleton pregnancy and who had gestational diabetes and fasting blood glucose concentrations ≥5.3 mmol/l and <7.8 mmol/l. Follow up was 100%.

    Intervention

    404 women were allocated to receive glyburide (n=201) or insulin (n=203). Glyburide was started at an oral dose of 2.5 mg and increased to 20 mg as needed. Insulin was started at a dose of 0.7 U/kg of actual body weight, given subcutaneously 3 times/day, and increased as needed. …

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    Footnotes

    • Source of funding: not stated.

    • For correspondence: Dr O Langer, Department of Obstetrics and Gynecology, St Luke's-Roosevelt Hospital Center, 1000 10th Avenue, New York, NY 10019, USA. Fax +1 212 523 8066.

    • ↵* See glossary.