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Budesonide and nedocromil did not improve lung function in children with asthma

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 QUESTION: In children with asthma, does continuous, long term treatment with budesonide or nedocromil improve lung function


Randomised {allocation concealed*}, {partially blinded (active treatment v placebo was blinded, but mode of treatment [steroid v non-steroid] was not)},* controlled trial with mean 4.3 years of follow up.


8 clinical centres in the US and Canada.


1041 children who were 5–12 years of age (mean age 9 y, 60% boys), had mild to moderate asthma, and had no other clinically significant condition. Follow up was 98% for lung function and ≥86% for diary outcomes.


Patients were allocated to 1 of 2 active agents or a matching placebo. Active agents were budesonide, 200 μg twice daily in two 100 μg puffs from a metered dose inhaler …

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