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Therapeutics
Racecadotril was effective for severe watery diarrhoea in children

https://doi.org/10.1136/ebm.6.3.87

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    (2000) N Engl J Med 343, 463. Salazar-Lindo E, Santisteban-Ponce J, Chea-Woo E, Gutierrez M.. Racecadotril in the treatment of acute watery diarrhea in children.. Aug 17;. :. –7.
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 QUESTION: In children with severe watery diarrhoea, is racecadotril (acetorphan, an enkephalinase inhibitor), as an adjunct to oral rehydration therapy, more effective than oral rehydration alone?

    Design

    Randomised {allocation concealed*}†, blinded {patients, clinicians, outcome assessors, and statisticians}†,* placebo controlled trial with 5 days follow up.

    Setting

    Hospital in Lima, Peru.

    Patients

    135 boys who were 3–35 months of age (mean age 13 mo) and had watery diarrhoea for ≥5 days, had passed ≥3 diarrhoeic stools within 24 hours of admission to the hospital, and had passed ≥1 diarrhoeic stool within 4–6 hours after admission. Exclusion criteria were blood in the stool, inability to drink, or any serious concomitant illness. 112 boys …

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