Article Text

Download PDFPDF

Review: small treatment effect of disodium cromoglycate in childhood asthma is tempered by methodological flaws and publication bias
Free

Statistics from Altmetric.com


 
 QUESTION: In children with asthma, how effective is inhaled disodium cromoglycate (DSCG)?

Data sources

Studies were identified by searching Medline, EMBASE/Excerpta Medica, the Cochrane Controlled Trials Register, and the database of the manufacturers of DSCG with the terms asthma, sodium cromoglycate, and clinical trial. Bibliographies of relevant studies were reviewed.

Study selection

English language studies were selected if they were randomised, double blind, placebo controlled trials of inhaled DSCG in the maintenance treatment of asthma in children up to 18 years of age. Studies of exercise induced asthma were excluded.

Data extraction

Data were extracted on methodological quality, setting, design, DSCG dose and method of administration, patient characteristics, duration of intervention, outcomes, and adverse effects. Symptom scores were calculated separately for wheeze and cough. Pooled estimates …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.