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Review: antiplatelet drugs reduce pre-eclampsia, preterm birth, and stillbirth or neonatal death

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 QUESTION: In pregnant women at risk for pre-eclampsia, how effective are antiplatelet drugs in preventing pre-eclampsia and its complications?

Data sources

Studies were identified by searching the Cochrane Pregnancy and Childbirth Group register of trials, the Cochrane Controlled Trials Register, and EMBASE/Excerpta Medica (1994–9) and by handsearching conference abstracts.

Study selection

Studies were selected if they were randomised controlled trials comparing antiplatelet drugs with placebo or no antiplatelet drug in women at risk for developing pre-eclampsia. Exclusion criteria were having no clinical data available, inadequate randomisation, <80% follow up of patients, or having participants at very low risk for pre-eclampsia.

Data extraction

Data were extracted on study validity (allocation concealment), patient risk for developing pre-eclampsia (high or moderate), length of gestation (< or ≥20 wks), dose of aspirin (≤75 mg or >75 …

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