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Therapeutics
Aspirin but not vitamin E prevented cardiovascular events in patients at risk

https://doi.org/10.1136/ebm.6.4.112

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    (2001) Lancet 357, 89. Collaborative Group of the Primary Prevention Project (PPP).. Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice.. Jan 13;. :. –95.
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 QUESTION: In patients with ≥1 cardiovascular risk factor but no history of cardiovascular disease, how effective is treatment with aspirin and vitamin E in preventing cardiovascular events?

    Design

    Randomised (allocation concealed*), unblinded,* 2 × 2 factorial trial with mean 3.6 years of follow up.

    Setting

    315 general practices and 15 hospital hypertension units in Italy.

    Patients

    4495 patients who were ≥50 years of age (mean age 64 y, 58% women) and had ≥1 major cardiovascular risk factor: age ≥65 years, hypertension, hypercholesterolaemia, diabetes mellitus, obesity, and family history of myocardial infarction (MI) before 55 years of age in ≥1 parent or sibling. Exclusion criteria were treatment with antiplatelet drugs, chronic use of anti-inflammatory agents or anticoagulants, contraindication to aspirin, disease with …

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    Footnotes

    • Sources of funding: Medical Department of Bayer Italy; aspirin preparation supplied by Bayer; vitamin E capsules supplied by Bracco SpA.

    • For correspondence: Dr M C Roncaglioni, Istituto di Ricerche Farmacologiche “Mario Negri,” Via Eritrea 62, 20157 Milan, Italy. Fax +39 02 39001916.

    • A modified version of this abstract also appears in Evidence-Based Nursing.

    • ↵* See glossary.