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Clopidogrel reduced recurrent ischaemic events in patients with previous cardiac surgery more than aspirin

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 QUESTION: In patients with recent ischaemic stroke, recent myocardial infarction (MI), or peripheral arterial disease and previous cardiac surgery, is clopidogrel more effective than aspirin in reducing recurrent ischaemic events?


Subgroup analysis of a randomised {allocation concealed*}, blinded {patients, clinicians, outcome assessors, and statisticians}* placebo controlled trial with 1–3 year follow up (mean 1.6 y) (Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events [CAPRIE] study).


{384 clinical centres in 16 countries}.


1480 patients (mean age 64 y, 84% men, 96% white) with recent stroke or MI or peripheral arterial disease who …

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  • Source of funding: no external funding.

  • For correspondence: Dr E J Topol, Department of Cardiology, F25, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Fax +1 216 445 9595.

  • * See glossary.

  • CAPRIE Steering Committee. Lancet 1996;348:1329–39.