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Clopidogrel reduced recurrent ischaemic events in patients with previous cardiac surgery more than aspirin
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 QUESTION: In patients with recent ischaemic stroke, recent myocardial infarction (MI), or peripheral arterial disease and previous cardiac surgery, is clopidogrel more effective than aspirin in reducing recurrent ischaemic events?

Design

Subgroup analysis of a randomised {allocation concealed*}, blinded {patients, clinicians, outcome assessors, and statisticians}* placebo controlled trial with 1–3 year follow up (mean 1.6 y) (Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events [CAPRIE] study).

Setting

{384 clinical centres in 16 countries}.

Patients

1480 patients (mean age 64 y, 84% men, 96% white) with recent stroke or MI or peripheral arterial disease who …

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