Article Text
Statistics from Altmetric.com
QUESTION: In patients who are receiving warfarin and have an international normalised ratio (INR) value between 4.5 and 10.0, does low dose vitamin K lower the INR better than placebo?
Design
Randomised (allocation concealed*), blinded {patients, clinicians, and outcome assessors}†,* placebo controlled trial with 3 months of follow up.
Setting
5 thromboembolism services at teaching hospitals in London and Hamilton, Ontario, Canada.
Patients
92 patients (mean age 65 y, 53% women) who were receiving warfarin and had an INR value between 4.5 and 10.0. Exclusion criteria were INR determined >12 hours before screening, life expectancy <10 days, need for immediate normalisation of INR, severe liver disease, major bleeding in the previous month, allergy to vitamin K, bleeding diathesis or thrombolytic treatment within 48 hours …
Footnotes
-
Source of funding: no external funding.
-
For correspondence: Dr M A Crowther, Room L208, St. Joseph's Hospital, Hamilton, Ontario L8N 4A6, Canada. Fax +1 905 521 6034.
↵† Information provided by author.