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  • Multicomponent comprehensive care was as effective as usual care for decreasing major bleeding in older patients on warfarin

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Therapeutics
Multicomponent comprehensive care was as effective as usual care for decreasing major bleeding in older patients on warfarin

https://doi.org/10.1136/ebm.6.4.116

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    (2000) Ann Intern Med 133, 687. Beyth RJ, Quinn L, Landefeld CS.. A multicomponent intervention to prevent major bleeding complications in older patients receiving warfarin. A randomized, controlled trial.. Nov 7;. :. –95..
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 QUESTION: In older patients requiring warfarin, is multicomponent comprehensive care (MCC) more effective than usual care for reducing major bleeding events?

    Design

    Randomised {allocation concealed*}†, blinded (data collectors and outcome assessors),* controlled trial with 6 months follow up.

    Setting

    Cuyahoga County, Ohio, USA.

    Patients

    325 patients (mean age 75 y, 57% women) who were ≥ 65 years of age, received ≥10 000 units of intravenous unfractionated heparin, resided in the area, and had planned warfarin treatment for ≥10 days. Exclusion criteria included treatment with warfarin in the previous 6 months, admission from a nursing home, or enrolment in another clinical trial. Follow up was complete.

    Intervention

    163 patients were allocated to MCC, which consisted of a guideline based consultation and patient education, coaching, and self monitoring of prothrombin time with a portable monitor. Home visits were made 3 days after discharge to assess the patients' ability …

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