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Therapeutics
Pseudoephedrine and acetaminophen relieved sinus symptoms in the course of the common cold

https://doi.org/10.1136/ebm.6.4.120

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    (2000) Arch Fam Med 9, 979. Sperber SJ, Turner RB, Sorrentino JV, et al.. Effectiveness of pseudoephedrine plus acetaminophen for treatment of symptoms attributed to the paranasal sinuses associated with the common cold.. Nov/Dec;. :. –85..
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 QUESTION: In patients with a cold, is a combination of pseudoephedrine hydrochloride and acetaminophen (PHA) more effective than placebo in relieving sinus symptoms?

    Design

    Randomised {allocation concealed *}†, blinded (clinicians and patients),* placebo controlled trial.

    Setting

    3 university medical centres in the eastern US.

    Patients

    430 patients who were 18–65 years of age (mean age 28 y, 66% women), had cold symptoms of ≤48 hours in duration, and reported sinus symptoms of at least moderate severity. Exclusion criteria were diastolic blood pressure >90 mm Hg, underlying illness that might be affected by the study drugs, use of medication that might interact with the study drugs, pregnancy, or potential for pregnancy. 412 patients (96%) completed the study.

    Intervention

    Patients were allocated to …

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    Footnotes

    • Source of funding: In part, Novartis Consumer Health Inc.

    • For correspondence: Dr S J Sperber, Infectious Diseases Division, Hackensack University Medical Center, 20 Prospect Avenue, Suite 507, Hackensack, NJ 07601, USA.

    • ↵* See glossary.

    • ↵† Information provided by author.