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Prognosis
Subsequent reactions were common and often more serious than the initial reactions of children with peanut allergy

https://doi.org/10.1136/ebm.6.4.126

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    (2000) J Pediatr 137, 749. Vander Leek TK, Liu AH, Stefanski K, et al.. The natural history of peanut allergy in young children and its association with serum peanut-specific IgE.. Dec;. :. –55..
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 QUESTION: In young children with peanut allergy diagnosed before 4 years of age, what is the nature and rate of adverse reactions caused by accidental peanut exposure?

    Design

    Cohort study with a median of 5.9 years (range 1.4 to 22.4 y) of follow up .

    Setting

    Boulder, Colorado, USA.

    Patients

    102 children with clinical peanut hypersensitivity diagnosed before their fourth birthday. Children were included if they had a convincing history of clinical peanut hypersensitivity; a positive double blind or a placebo controlled food challenge response to peanuts, or both; and a positive skin prick test response to peanuts. Data for 83 children (81%) (median age 2.4 y, 69% boys) were available for the analysis.

    Assessment of prognostic factors

    Initial assessment records: severity of symptoms (non-life threatening or potentially life threatening); organ system involvement (skin, respiratory, gastrointestinal, or other); and serum peanut specific immunoglobulin E (IgE) concentrations (in 51 of 83 [61%] children).

    Main outcome measures

    Subsequent adverse reactions after a first peanut exposure were assessed at least …

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    Footnotes

    • Source of funding: no external funding.

    • For correspondence: Dr S A Bock, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Room J211, Denver, CO 80206, USA. Fax +1 303 443 5030.

    • A modified version of this abstract appears in Evidence-Based Nursing.