Article Text

Download PDFPDF
Review: mefloquine prevents malaria but has adverse effects that limit its acceptability in adults not immune to malarial infection

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 QUESTION: In adult travellers not immune to malarial infection, is mefloquine more effective than placebo or other prophylaxis for preventing malarial episodes and adverse events?

Data sources

Published and unpublished studies were identified by searching Medline, EMBASE/Excerpta Medica, and LILACS from 1966 to July 2000; the Cochrane Infectious Diseases Group (to July 2000); and Science Citation Index; by handsearching 2 military medical journals {1945 to 1999}*; and by handsearching for several subsequent issues the correspondence pages of journals yielding a published trial. Bibliographies of retrieved papers and standard textbooks of tropical medicine and conference proceedings were also searched. Personal contact was made with pharmaceutical companies, authors, and investigators.

Study selection

Randomised or quasirandomised controlled trials were selected if participants were adults not immune to malaria, were prescribed prophylactic drugs for <12 months, and were …

View Full Text


  • Source of funding: Department for International Development UK.

  • For correspondence: Dr A M Croft, Surgeon General's Department, Ministry of Defence, Whitehall, London SW1A 2HB, UK. Fax +44 (0)207 807 8834.

  • * Information provided by author.