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  • Review: mefloquine prevents malaria but has adverse effects that limit its acceptability in adults not immune to malarial infection

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Therapeutics
Review: mefloquine prevents malaria but has adverse effects that limit its acceptability in adults not immune to malarial infection

https://doi.org/10.1136/ebm.6.5.143

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    . Croft AM, Garner P. Mefloquine for preventing malaria in non-immune adult travellers. Cochrane Database Syst Rev 2001;(1):CD000138 (latest version 28 Aug 2000)..

    
 
 QUESTION: In adult travellers not immune to malarial infection, is mefloquine more effective than placebo or other prophylaxis for preventing malarial episodes and adverse events?

    Data sources

    Published and unpublished studies were identified by searching Medline, EMBASE/Excerpta Medica, and LILACS from 1966 to July 2000; the Cochrane Infectious Diseases Group (to July 2000); and Science Citation Index; by handsearching 2 military medical journals {1945 to 1999}*; and by handsearching for several subsequent issues the correspondence pages of journals yielding a published trial. Bibliographies of retrieved papers and standard textbooks of tropical medicine and conference proceedings were also searched. Personal contact was made with pharmaceutical companies, authors, and investigators.

    Study selection

    Randomised or quasirandomised controlled trials were selected if participants were adults not immune to malaria, were prescribed prophylactic drugs for <12 months, and were …

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    Footnotes

    • Source of funding: Department for International Development UK.

    • For correspondence: Dr A M Croft, Surgeon General's Department, Ministry of Defence, Whitehall, London SW1A 2HB, UK. Fax +44 (0)207 807 8834.

    • ↵* Information provided by author.