Statistics from Altmetric.com
QUESTION: In patients with mechanical prosthetic heart valves, are combined oral anticoagulants and antiplatelet treatment more efficacious than anticoagulants alone?
Studies were identified by searching Medline (1966 to November 1999) with the terms heart valve prosthesis, mechanical heart valve, thromboembolism, anticoagulant, antiplatelet, and haemorrhage. Bibliographies of studies, reviews, meta-analyses, and consensus statements were also checked.
Full text and abstracts of randomised controlled trials were selected if patients with prosthetic heart valves were studied, oral anticoagulation plus antiplatelet agents were compared with oral anticoagulation alone, and objective methods were used to assess outcomes and adverse effects.
Data were extracted on study characteristics and quality; interventions, including type and duration of anticoagulation and antiplatelet agents; target international normalised …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.