You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Reduced sodium intake lowered blood pressure and need for antihypertensive medication

https://doi.org/10.1136/ebm.6.5.151

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (2001) Arch Intern Med 161, 685. Appel LJ, Espeland MA, Easter L, et al.. Effects of reduced sodium intake on hypertension control in older individuals. Results from the Trial of Nonpharmacologic Interventions in the Elderly (TONE).. Mar 12;. :. –93.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 QUESTION: In older adults with hypertension, is a reduced dietary sodium (RS) intervention more effective than usual lifestyle (UL) in controlling blood pressure and preventing cardiovascular events?

    Design

    Randomised {allocation concealed*}†, blinded (outcome assessors),* controlled trial with 30 months follow up.

    Setting

    4 clinical centres in the US.

    Patients

    681 patients who were 60–80 years of age (mean age 66 y, 53% men) and had systolic blood pressure (SBP) <145 mm Hg and diastolic blood pressure (DBP) <85 mm Hg while taking 1 antihypertensive medication (AM). Exclusion criteria were use of AM for conditions other than hypertension, myocardial infarction (MI) or stroke in the previous 6 months, angina pectoris, congestive heart failure (CHF), serum creatinine concentration >176.8 μmol/l, blood glucose concentration >14.4 mmol/l, or average alcohol intake >14 drinks per week. Follow …

    View Full Text

    Footnotes

    • Source of funding: National Institutes of Health.

    • For correspondence: Dr L J Appel, Johns Hopkins University, 2024 East Monument Street, Suite 2-645, Baltimore, MD 21205-2223, USA.

    • ↵* See glossary.

    • ↵† Information provided by the author.

    • ↵‡ Whelton PK, Appel LJ, Espeland MA, et al. JAMA 1998;279:839–46.