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  • Permethrin (PER) plus trimethoprim/sulfamethoxazole (TMP/SMX) was better than PER but not TMP/SMX for head lice infestation in children

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Therapeutics
Permethrin (PER) plus trimethoprim/sulfamethoxazole (TMP/SMX) was better than PER but not TMP/SMX for head lice infestation in children

https://doi.org/10.1136/ebm.6.5.152

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    (2001) Pediatrics 107, E30. Hipolito RB, Mallorca FG, Zuniga-Macaraig ZO, et al. . Head lice infestation: single drug versus combination therapy with one percent permethrin and trimethoprim/sulfamethoxazole.. Mar;. :. ..
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 QUESTION: Is a combination of topical permethrin (PER) and oral trimethoprim/sulfamethoxazole (TMP/SMX) better than either PER or TMP/SMX alone for treating head lice infestation (HLI)?

    Design

    Randomised (unclear allocation concealment*), blinded (unclear),* controlled trial with 4 weeks follow up.

    Setting

    3 private paediatric and family practices in San Joaquin County, California, USA.

    Patients

    115 children who were 2–13 years of age (70% girls) and were diagnosed with HLI (clinical suspicion of lice or eggs). Children with hypersensitivity to TMP/SMX or 1% PER or with a history of parental non-compliance or neglect were excluded from the study. 97% of children completed follow up.

    Intervention

    In all treatment groups, parents were instructed to first wash their child's hair with regular shampoo and then rinse. 39 children were allocated to 1% PER, for which parents were …

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    Footnotes

    • Source of funding: not stated.

    • For correspondence: Dr R B Hipolito, University of California at Davis, School of Medicine, Department of Pediatrics, Section of Neonatology, TB 193, Davis, CA 95616, USA. rbhipo{at}aol.com.

    • A modified version of this abstract also appears in Evidence-Based Nursing.

    • ↵* See glossary.

    • ↵† p Values calculated from data in article.