Article Text

Download PDFPDF
Bucindolol reduced mortality and hospitalisation related to cardiovascular causes in advanced chronic heart failure

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 QUESTION: In patients with advanced chronic heart failure, does bucindolol reduce all-cause mortality, cardiovascular mortality, and hospitalisation for chronic heart failure?


Randomised (allocation concealed*), blinded (clinicians and patients),* placebo controlled trial with mean follow up of 2 years (Beta-Blocker Evaluation of Survival Trial [BEST]).


90 clinical sites in the USA and Canada.


2708 patients (mean age 60 y, 78% men). Inclusion criteria were New York Heart Association (NYHA) class III or IV chronic heart failure caused by primary or secondary dilated cardiomyopathy; left ventricular ejection fraction ≤ 35%; optimal medical treatment, including angiotensin-converting enzyme inhibitors for ≥ 1 month; and ≥ 18 years of age. Exclusion criteria included reversible heart failure; uncorrected primary valvular disease; active myocarditis; recent myocardial infarction or revascularisation; unstable angina; heart rate < 50 beats/minute; or serious concomitant illness.


Patients were allocated to bucindolol, 3 mg twice daily for 1 week, which was then titrated gradually to a maximum dose of 100 mg twice daily (n=1354) or to placebo (n=1354).

Main outcome measures

All-cause mortality, cardiovascular mortality, and hospitalisation related to chronic heart …

View Full Text


  • Sources of funding: US National Heart, Lung, and Blood Institute; Department of Veterans Affairs Cooperative Studies Program; Incara Pharmaceuticals (drugs).

  • For correspondence: Dr E J Eichhorn, Cardiac Catheterization Laboratory (IIIA2), University of Texas Southwestern and Dallas Veterans Affairs Medical Center, 4500 South Lancaster, Dallas, TX 75216, USA. Fax +1 214 857 1474.

  • * See glossary.