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Changes in diet and physical activity prevented type 2 diabetes mellitus in people with impaired glucose tolerance

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 QUESTION: In patients with impaired glucose tolerance, is a lifestyle intervention programme effective for preventing type 2 diabetes mellitus?


Randomised (allocation concealed*), unblinded,* controlled trial with mean follow up of 3.2 years (the Finnish Diabetes Prevention Study).


5 locations in Finland (Helsinki, Kuopio, Oulu, Tampere, and Turku).


522 patients between 40 and 65 years of age (mean age 55 y, 67% women) who were overweight (body mass index ≥ 25 kg/m2) and had impaired glucose tolerance (mean plasma glucose level between 7.8 and 11.0 mmol/l 2 h after receiving 75 g of oral glucose on 2 occasions, in patients with plasma glucose levels < 7.8 mmol/l after an overnight fast). Exclusion criteria included diabetes mellitus and advanced chronic disease. Follow up …

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  • Sources of funding: Finnish Academy; Ministry of Education; Novo Nordisk Foundation; Yrjö Jahnsson Foundation; Finnish Diabetes Research Foundation.

  • For correspondence: Professor J Tuomilehto, National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Mannerheimintie 166, FIN-00300 Helsinki, Finland. Fax +35 89 4744 8338.

  • * See glossary.