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Therapeutics
Prenatal and postnatal administration of Lactobacillus GG reduced the occurrence of atopic disease in offspring

https://doi.org/10.1136/ebm.6.6.178

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    (2001) Lancet 357, 1076; Kalliomäki M, Salminen S, Arvilommi H, et al.. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial.. Apr 7;. :. –9.
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 QUESTION: In offspring at risk for atopic disease, does oral administration of Lactobacillus GG (LGG), given prenatally to mothers and postnatally to their infants, prevent atopic eczema?

    Design

    Randomised (unclear allocation concealment*), blinded (clinicians, patients, and outcome assessors),*) controlled trial with 2 years of follow up.

    Setting

    Antenatal clinics in Turku, Finland.

    Patients

    159 pregnant women who had atopic disease, or ≥ 1 first-degree relative (mother, father, or older sibling), or partner with atopic eczema, allergic rhinitis, or asthma. 132 women (83%) and 132 children completed follow up.

    Intervention

    Mothers were allocated to LGG (1 × 1010 colony-forming units [Valio Limited, Helsinki, Finland]) (n=77) or to placebo (microcrystalline cellulose) (n=82). The capsules were taken daily for 2 to 4 weeks before expected delivery. After delivery, …

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