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QUESTION: In Vietnamese children who are 2 to 5 years old, does vaccination with Salmonella typhi Vi conjugate vaccine reduce the incidence of typhoid fever?
Randomised (allocation concealed*), blinded (participants and outcome assessors),* placebo controlled trial with 27 months of follow up.
16 communes in Dong Thap Province, Vietnam.
12 008 children who were 2 to 5 years of age (51% boys). Children with illness that required ongoing medical care were excluded. 92% of children received 2 correctly labelled injections and completed the study.
5991 children were allocated to S typhi Vi conjugate vaccine (2 doses of 22.5 μg of capsular polysaccharide and 22 μg of Pseudomonas aeruginosa exotoxin A in 0.5 ml of phosphate-buffered saline containing 0.01% thimerosal), and …
Sources of funding: in part, National Institute of Child Health and Human Development and Aventis Pasteur.
For correspondence: Dr FY Lin, National Institute of Child Health and Human Development, Room 7B03, 6100 Executive Boulevard, Bethesda, MD 20892-7510, USA. Fax +1 301 402 2084.